Disseminated tuberculosis in relatively asymptomatic young woman.

Madhyastha SP, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-219276 Description A previously healthy 20-year-old woman presented to the emergency department with a history of one episode of generalised tonic– clonic seizure. No history of fever or constitutional symptoms. At admission, she was haemodynamically stable and Glasgow Coma Scale was 8, with no focal neurological deficits. For the workup of seizures, MRI brain (figure 1) was done which revealed multiple ring-enhancing lesions in bilateral temporal, frontal and right parietal lobes. Cerebrospinal fluid examination showed normal cell count with high protein (84 mg/dL) and normal glucose levels (43 mg/dL), and high adenosine deaminase (9.3 U/L) level. Chest X-ray showed (figure 2A) miliary mottling which was confirmed by contrast-enhanced CT (CECT) chest (figure 2B and C). CECT abdomen (figure 3A and B) revealed thick-walled multiloculated collection (7.3×8.4×14.2 cm) with thick internal septations in the left lumbar and iliac fossa region. Pelvic collections were drained with an image-guided pig tail insertion and pus was sent for analysis which revealed acid-fast bacilli. The Mycobacterium tuberculosis was sensitive to isoniazid and rifampicin. HIV ELISA was non-reactive, CD4 counts and her immunoglobulin levels were normal. An enquiry about her immunisation status revealed that she had received Bacillus Calmette-Guerin vaccination at birth. The patient was treated with antitubercular therapy, steroids and antiepileptic drugs. Clinically, sensorium improved and she was discharged after 2 weeks with an advice to continue antitubercular therapy and a tapering dose of steroids. Follow-up images (figure 4) after 3 months showed complete resolution of pelvic collection. Tuberculosis is widely prevalent in India and accounts for one-fourth of the global TB burden. Disseminated tuberculosis refers to concurrent involvement of at least two non-contiguous organ sites of the body. It also refers to involvement of blood or bone marrow by tuberculosis process. Miliary tuberculosis is a form of disseminated tuberculosis due to haematogenous dissemination of tubercle bacilli. This results in tiny discrete foci usually the size of millet seeds, uniformly distributed in the lungs and other viscera. Disseminated and miliary tuberculosis can involve any organ in the body. Our patient had multiple tuberculomas in the brain, miliary tuberculosis and pelvic collection. Diagnosis is Disseminated tuberculosis in relatively asymptomatic young woman Sharath P Madhyastha, Vinaya Gopalaswamy, Raviraja V Acharya, Akhila Doddamani Images in...